In their last eight interconference matchups, the Cardinals are 7-1-0 ATS. That includes a perfect 4-0 record this season. Arizona is also 3-1 (3-1-0 ATS) in their last four home games. New England's o-line is 28th in sacks allowed, an area where the Cardinals (12th in sacks) should feast. Arizona's defense will be fine against an offense that's 31st in scoring and 29th in yards per play. Offensively, the Patriots don't have the personnel to contain Kyler Murray. New England has been worse on the road all season, including a 2-4-0 ATS record in their last six away games. Roll with the Cards ATS.