The Rams opened the season with an upset win at Seattle, but that puts them in a potential letdown spot here and they'll face a much tougher test here in Week 2 as divisional rivals San Francisco 49ers come to Inglewood.

The Niners are one of the favorites to win the Super Bowl, and they have owned the Rams in recent seasons, going 8-2 ATS in the last 10 meetings.

The Rams managed to put up 30 points on Seattle, but now they'll face arguably the best defense in the league and a quarterback that in Brock Purdy who has yet to lose a regular season game.

Since the start of the 2021 season, the Niners are 23-9 SU and 20-12 ATS as favorites and 16-4 SU and 13-7 ATS as a favorite of 3.5 to 9.5 points. They are also 10-4 ATS against divisional opponents.

Bet this free pick on the 49ers with 2% of your bankroll.

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