The Giants got stomped by Dallas in Week 1, and they needed a 17-0 fourth quarter to scrape by a weak Arizona team in Week 2. Here they'll have to do without star RB Saquon Barkley who left the win against Arizona early with an ankle injury, and I just don't see how the Giants will be able to keep up with a Niners team that is superior on both sides of the ball.

The Niners are 2-0 on the season after winning 30-7 at Pittsburgh in Week 1 and 30-23 at LA Rams in Week 2. Two dominant performances, and their Week 2 win could've/should've been bigger. I expect the 49ers to rout their opponent here in their home opener.

Bet this TOP PLAY on the 49ers with 4% of your bankroll.