Point Spread: -3.00 | -118.00 San Francisco (Away)
St. Louis permits nearly 30 points a game and is second-to-last in stopping the run. The Rams have allowed 100-yard rushers in three of their last four games.
Don't be fooled by the Rams ranking No. 1 in pass defense. Their secondary actually isn't very good at all. They've faced the fewest pass attempts per game. Opposing quarterbacks have completed close to 71 percent of their throws against the Rams. The Rams are last in the league in sacks, too, with just one.
San Francisco owns the superior offense and defense. The 49ers are 8-1-1 ATS in their last 10 road and neutral site games, not including playing in Seattle.