Point Spread: 20.50 | -107.00 Indiana (Away)
Note that the Buckeyes have not played since November 7 as last week's scheduled matchup with Maryland was canceled following a COVID-19 outbreak in the Terrapins' program. While rest is mostly beneficial, there's also a risk of the Buckeyes coming out a bit rusty, something they can't afford to do when asked to cover a spread this big.
Indiana has held opponents to an average of 19.3 points per game, and while Ohio State is a different beast than the other teams they have faced, I still like the Hoosiers to keep this within the number.
8* play on Indiana.