This is a 10* BOOKIEKILLER on the 49ers.

This game is being played in Mexico City, and it's won that I believe favors the 49ers in a big way.

Arizona is coming off a 27-17 win over the Rams, while San Francisco is off a 22-16 win over the Chargers.

This is the first meeting of the season between the division rivals, as they also end the regular season facing each other.

The 49ers have made some moves before the deadline and now with Elijah Mitchell back, Jimmy Garoppolo has a very explosive unit around him again. He can go back to simply managing games and looking better than he really is.

Especially with this aggressive 49ers' defense. San Fran is 5-0 ATS in its last five vs. the NFC West and 9-2 ATS in its last 11 vs. the NFC overall.

Previous to last week's win, the Cards had dropped two straight. Interestingly the Cards are just 2-9 ATS in their last 11 MNF contests.

Colt McCoy is likely going to be called into action here for Arizona, so I give a big nod to Garoppolo and this much-improved 49ers' offense.

Lay the points, the play is SAN FRANCISCO.

Good luck, NP