Both teams are dealing with injuries but more notable are the injuries on the Cardinal's offensive side of the ball. They are banged up at all key skill positions with Kyler Murray, Andre Hopkins, and Chase Edmunds all listed as questionable and they did not practice Thursday. The 49ers have one of the league’s top defenses and will be able to slow down the Cardinal's offense. Even if Murray does play, which I suspect he does, his ankle injury will limit what he can do. Arizona has gone under the total in seven of its last 10 games, despite having a top 10 offense. These teams have played under the total in seven of their last 10 head-to-head meetings.

Play on the UNDER.