This is a classic let down spot for a very good Louisville team that gave everything in their game last week against Notre Dame. This is also a look ahead spot for the Cardinals as they have Duke on deck. Pittsburgh is off their bye and an underdog at home. QB Jurkovek has been terrible and the coach made the change and inserted the back up quarterback Christian Veilleux as starter and put Jurkovek at TE. Narduzzi is riding a four game losing streak and a shakeup was warranted. They are strong on defense and have a strong run defense. This will be a kitchen sink type of game where all hands will be on deck for the Panthers and with bad weather threatening to muck this game up, the Panthers have a great chance of keeping this game close and winning it outright.

Louisville as a favorite of 3.5 to 10 points are 0-3 ATS this season. Louisville off a home win are 0-2 ATS this season and only 5-6 ATS in the last three seasons. The Panthers off an upset loss as a favorite are 3-1 ATS in the last three seasons. The Panthers after allowing 37 points or more last game are 4-1 ATS in the last three seasons. Louisville are 2-6-1 ATS in their last 9 games against Pittsburgh. Louisville are 2-4 SU in their last 6 games when playing on the road against Pittsburgh. Pittsburgh are 4-1 ATS in their last 5 games against an opponent in the Atlantic Division division.

Best bet: take the points with Pittsburgh.