Neither defense has been strong due to injuries up til now but Seattle's is in worse shape. San Francisco has been able to fill the hole of McCaffrey somewhat by plugging in Jordan Mason and he has played well with a few hiccups. San Francisco has a good ground game that should open up the pass game. This team will be desperate and this is an important divisional game so this is a must win game for the 49’s. Jared Goff and to a lesser extent, Daniel Jones, were both able to expose the Seahawks secondary by putting up points, and that bodes well for Purdy who can replicate that success, and they do have the advantage in the air as they are the number 2 passing team. Both Debo and Purdy didn’t have great games but expect them to step up in this game and perform well. They can take advantage of Seattle’s problem with racking up more penalties than most teams and who are starting to turn the ball over more as the season goes along. Purdy is 4-0 straight up against Seattle and the team has won the last five straight against the Seahawks. Look for San Francisco to get back on track.

Best bet: lay the small number with San Francisco.