This game should see points as the 49’s establish the run game that will open up the pass game for them and this is what happened against Seattle when they first played Detroit as Goff carved up the secondary and to a lesser extent, Daniel Jones was able to to do the same on a smaller scale, and that game saw 49 points. Detroit’s game went well over the total. Expect the same with Purdy at helm. Both offenses can move the ball in this game, and with Seattle’s fresh injuries on the offensive line and defensive line, the 49’s should be able to get more points. Seattle will do their share in getting this total to go over. San Francisco is 3-2 to the Over this season while Seattle is 2-1 to the Over at home. Head to head, they have gone 5-3-2 to the Over.

Best bet: take the Over the Total.