The Rams vs. 49ers matchup sets the stage for a potential high-scoring affair, with both teams showcasing offensive firepower and notable defensive vulnerabilities. The Rams’ defense has struggled, allowing 6.9 net yards per pass attempt, ranking second-worst in the league, which the 49ers’ efficient passing attack—averaging 7.7 net yards per attempt, third-best in the NFL—should exploit.

Recent matchups support a high total, with their last meeting on September 22, 2024, combining for 51 points (Rams 27, 49ers 24), surpassing the current over/under line of 48.5. Additionally, the Rams scored 41 points against the 49ers in a prior game, highlighting their ability to put up big numbers.

Both defenses have struggled to make stops, with the 49ers ranking 6th-worst on third-down defense and 2nd-worst in the red zone, offering the Rams opportunities to extend drives and score. Historical trends also favor a higher-scoring outcome, with the teams combining for an all-time average of 43.9 points per game.

Considering these factors—offensive strengths, defensive weaknesses, and recent high-scoring trends—the Over 48.5 looks like a strong play for this divisional clash.