Kyle Shanahan's teams are 43-18 after their bye week. This San Fran offense, second in yardage and seventh in scoring, gets back Christian McCaffrey today. Tampa's defense is 30th in yards and 28th in scoring. That'll be a complete mismatch. On the other side of the ball, the 49ers are 10th in yards allowed per game. Against a Bucs offense missing Chris Godwin and Mike Evans, they should be fine. The turnover battle should also favor the 49ers. Expect them to win in a big way.