The Saints have the worst defense in the league and are on the road. Not a good combination.

Chuck Pagano isn't the sharpest coach around that's for sure. But the Colts do play hard for him. They have a great track when playing bad teams - 19-4 ATS versus foes under .500. Indianapolis also is 17-3 ATS following a loss.

Andrew Luck showed enough against the Patriots that he's past his shoulder injuries. to be trusted to put up a lot of points, especially against this opponent. Luck is 21-7 at home compared to 16-14 when on the road.

Luck should light up a Saints secondary that has permitted 11 touchdown passes and has only two interceptions and is allowing 8.6 yards per pass.