Whenever I see the Twins open as a favorite my first look always is to the underdog. Fading the Twins today should be worth the investment.

The pitching matchup is a pair of right-handers, Cody Anderson of the Indians versus journeyman Ricky Nolasco. Cleveland has won the last four times it has faced a righty starter, while the Twins are 6-14 in their last 20 games versus a right-hander.

Anderson showed promise as a rookie last season going 7-3 with a 3.05 ERA in 15 starts. But he hasn't pitched well in his first 14 1/3 innings this season. Anderson is better than his 7.53 ERA and Nolasco is much worse than his 2.66 ERA.

Anderson was 2-0 with a 2.86 ERA in his last two starts against Minnesota in 2015. The Indians should be pumped more than normal for this game with Michael Brantley starting for the first time this season after more than five months of rehab following right shoulder surgery. Manager Terry Francona calls the talented Brantley the heart and soul of the Indians.

The 33-year-old Nolasco was one of the worst starting pitchers in the majors last season finishing the year 11-14, with a 5.64 ERA and 1.55 WHIP. Opponents batted .317 against him. Nolasco may be throwing his slider more this year, but he's still who he is. He's due for a huge regression.

The Twins also have serious fatigue issues in their bullpen. Minnesota relievers have worked 15 2/3 innings during the last two days. The Twins remain without their injured closer, Glen Perkins.

(Editor's note: Stephen Nover is 4-0 on his free MLB plays this season.)