Decimated San Francisco has lost 18 players for the season, including Carlos Hyde. Colin Kaepernick is going to have problems trying to figure out Seattle's defense, which does a great job of containing dual-threat quarterbacks, and doesn't have any reliable weapons anymore with Hyde getting hurt last week.

The 49ers have covered just three of their last 14 games. Their defense is worn down from multiple injuries and being on the field way too much. A healthy Russell Wilson can take advantage. Seattle has a mediocre offensive line, but the 49ers are one defense they can control.

The Seahawks will be fired up, too, after suffering an embarrassing defeat at home to the Cardinals. Pete Carroll certainly doesn't want to enter the playoffs off two straight poor performances and with playoff positioning still at stake.

The 49ers pulled out their second win of the season this past Saturday against the Rams. They're totally outmatched here.