No, not without Jimmy Garoppolo can the 49ers lay this many points, especially given their battered condition.

San Francisco is 1-11 in their last 12 games when Garoppolo hasn't been its starting quarterback. C.J. Beathard is back behind center with Garoppolo done for the season. The 49ers also are without tailback Jerick McKinnon and maybe their best offensive lineman as Joe Staley was injured this past Sunday.

The Cardinals are 0-4, the lone remaining winless team in the NFL. They are desperate for a victory. The 49ers haven't defeated the Cardinals since Jim Harbaugh was their coach.

Arizona has improved each week. The Cardinals lost at the gun, 20-17, to the Seahawks this past Sunday and were leading the Bears with under five minutes left two weeks ago before losing, 16-14.

The Cardinals are far more competive with rookie Josh Rosen at quarterback rather than timid Sam Bradford. Rosen played a good game against the Seahawks in his first NFL start. He was 15-of-27 for 180 yards with one touchdown pass and no interceptions. He had completions to seven different receivers. His statistics would have looked better if not for five dropped passes.

Rosen faces a 49ers defense that lacks edge pass rushers and has multiple injuries to their secondary with cornerback Richard Sherman and safety Jaquiski Tartt both out. I like Rosen better than Beathard plus Arizona has the most dynamic offensive player, David Johnson. It wouldn't surprise me if the Cardinals won this game straight-up.