The Browns' offense has shown signs of getting in gear coming off a 40-point performance against the Ravens last week. Baker Mayfield has two of the best at their respective positions in wide receiver Odell Beckham Jr. and running back Nick Chubb. It's a plus for the Browns and Over that Jarvis Landry should be able to play. 
The 49ers' defense is improved, but still striving to turn the corner. San Francisco has been fortunate so far to draw the Buccaneers in Tampa Bay's first game under new coach Bruce Arians, a weak Bengals offense and a Steelers offense that had Mason Rudolph behind center instead of Ben Roethlisberger. 
Cleveland's defense could be missing its starting cornerbacks as both Greedy Williams and Denzel Ward are injured. It's alarming that the Browns defense surrendered 43 points to Tennessee. The Titans have scored a combined 55 points in their four other games. 
San Francisco's offense is getting dangerous with Jimmy Garoppolo getting the rust off behind offensive guru Kyle Shanahan's well-designed plays. The 49ers have three solid running backs, underrated wide receivers and a top-two tight end in George Kittle. Shanahan has had two weeks to prepare for this matchup. 
Note, too, that this will be Jerome Boger's crew who will be doing the officiating. Boger is infamous for his frequent defensive holding calls. The Over has covered 59 percent of the time in Boger's 164 games.