The Giants are home, have a huge scheduling advantage and get back Saquan Barkley and Evan Engram. Barkley is a top-three running back and I rate Engram as a top-five tight end. 
The Cardinals have a porous defense ranking among the bottom-four in several key statistical categories, including yards allowed, points and pass defense. The return of cornerback Patrick Peterson from suspension is a plus for the Cardinals, but doesn't move the needle nearly enough. 
The Cardinals are coming off a 34-33 home victory against the Falcons. The Cardinals achieved the victory when normally reliable veteran Matt Bryant missed an extra point after the Falcons scored a touchdown with less than two minutes left. The Cardinals nipped the Bengals at the gun on a field gun two weeks ago. The Falcons and Bengals are a combined 1-11. The spread would be much higher here if the Cardinals held a 0-5-1 mark instead of a far more respectable 2-3-1 record. 
This also is Arizona's longest trip of the season and it's at an early West Coast start time. The Cardinals are 2-9 ATS in their last 11 Eastern Standard Time games. The Giants are on extra rest having played last Thursday.