If the Broncos thought they could make a successful run with Joe Flacco at quarterback they were sadly delusional. It took a 30-6 home loss to the Chiefs last Thursday to figure that out. Now, at 2-5, the Broncos know they are dead. Only seven teams during the last 40 years have made the postseason after opening 2-5.
Emmmanuel Sanders, Denver's best wideout, got traded. Others are likely to follow before Tuesday's trade deadline concludes. 
Unless Dwayne Haskins becomes the Redskins new first-stringer, Flacco is the worst starting QB in the NFL. And Garett Bolles may be the worst offensive left tackle in the league. It's a lethal combination that sinks the Broncos' popgun offense that has failed to break 16 points in five of their seven games.  
The Broncos' defense is good, but not great. Certainly it's not nearly strong enough to carry such a putrid offense. 
The Colts have proven time after time under Frank Reich that they are legitimate. Indy's defense has back it's best playmaker, linebacker Darius Leonard, and top defensive back in free safety Malik Hooker. 
The Colts are balanced on offense with Jacoby Brissett coming off a confidence-building four-touchdown performance in a 30-23 home win against Houston last Sunday. 
When you factor in home field advantage and the Colts being without a major weakness, this line comes up short.