No Kerryon Johnson means no more emphasis from the Lions on a ground attack. Detroit doesn't need one thanks to a strong bounce back season from Matthew Stafford, who has a 16-to-4 touchdown-to-interception ratio and three solid wide receivers in Kenny Golladay, Marvin Jones and Danny Amendola. 
The Raider rank 28th in scoring defense and 31st in pass defense. They are without their two best guys in the secondary with Jonathan Abram injured and Gareon Conley traded. The Lions should have a great deal of success throwing here.
Oakland, though, is playing well offensively ranking sixth in yards per play. The Raiders haven't allowed a sack in the last three weeks. Derek Carr has thrown just one interception in the last five games and Josh Jacobs has come through at running back. 
The Lions are banged-up in the secondary, too, with cornerbacks Darius Slay and Rashaan Melvin each injured. Detroit traded safety and team leader Quandre Diggs. Carr should have time to throw as the Lions have had zero or one sack in three of their last four games.