Russell Wilson is the best QB in the NFL right now. I want Wilson going for me with this many points on the Monday Night Football center stage. Seattle has covered the last eight times it has been an underdog, including both times this season.
The 49ers are the most improved team in the league. But now they have the bullseye and pressure on them to only win, but cover margins, too. They lack Seattle's prime time big-game experience and record.
The Seahawks are well-balanced with a respectable ground attack and now three dangerous wide receiving targets for Wilson with Josh Gordon joining Tyler Lockett and DK Metcalf. 
San Francisco suffered an unsung defensive injury with linebacker Kwon Alexander out for the year with a torn pec muscle. Alexander was the 49ers' second-leading tackler. The 49ers also have been missing their starting offensive tackles and star fullback Kyle Juszcyzk is out, too. in addition, star tight end George Kittle is at less than 100 percent.
Seattle has dominated this series winning 10 of the past 11 meetings going 7-3-1 ATS.