I like the Colts on extra rest off a loss. They catch the Titans fat and happy. Tennessee just posted home victories against the Jaguars and Chiefs. Now the Titans go on the road for the first time in four weeks. They lost their past two road games - 30-20 to the Panthers and 16-0 to the Broncos. The Colts are better than both of those teams. 
Indy has dominated the Titans at home going 10-1 SU, 9-1-1 ATS the past 11 times. The Colts also have covered 11 of the last 12 times when meeting an above .500 foe.
Tennessee has a key below-the-radar injury with cornerback Malcolm Butler out. LeShaun Sims is Butler's replacement and that's a huge downgrade. T.Y. Hilton can exploit that.