Weather is going to factor in this game with heavy winds projected. The Browns are a running team, while the Raiders rely far more on the pass. So the conditions favor Cleveland. 
The Browns' strength is running the ball. Kareem Hunt is good enough to carry the load without Nick Chubb. The Raiders are giving up 32.8 points per game, 2nd-highest in the NFL. Baker Mayfield should be able to pick his spots in favorable yardage situations.
The Browns have been opportunistic. They lead the NFL with 14 takeaways. The Raiders are minus 5 in turnover differential. 
Note this is an early start for the Raiders. The Raiders are 3-10 SU, 4-9 ATS when playing in the Midwest or East Coast under Jon Gruden with an averaging losing margin of 13 points.