The combination of injuries and COVID have destroyed the 49ers for much of the season. This situation is at its worst for the 49ers in this Thursday game.
Not only do the 49ers have a cluster injury problem in their defensive line and injuries in their secondary, but their offense is now devastated, too. San Francisco has to play this game minus starting QB Jimmy Garoppolo, star tight end George Kittle, left tackle Trent Williams plus be without its top running back, Raheem Mostert, and its three top wide receivers! 
Talk about a depleted roster. Green Bay is likely down its three best running backs as Jamaal Williams and AJ Dillon are out and I don't expect Aaron Jones to play either. But Aaron Rodgers can overcome this because the Packers have a diverse offense with many short passing options. 
The Packers are averaging 31.3 points, third-best in the NFL. 49ers QB Nick Mullens operating an offense devoid of weapons will not be able to match Rodgers.