Don't let the season defensive statistics of these two teams fool you. The stats are skewed. The Bills are healthier on defense now and Seattle has two key defensive reinforcements - All-Pro safety Jamal Adams and two-time Pro Bowl defensive end Carlos Dunlap. 
Seattle's defense looked sharp for three quarters last week holding the 49ers to 117 yards, but let up during fourth quarter garbage time after building a 23-point lead. Adams is that rare defensive player who could be worth something on the betting line that isn't being reflected. 
The Bills are averaging just 18.7 points during their last four games. They could be without center Mitch Morse (concussion) and deep threat John Brown (knee). The Bills are a ground-oriented team that will try to control the clock to keep the ball away from Russell Wilson.
Buffalo's defense hasn't been as dominant as last season somewhat in part due to multiple injuries. The Bills are healthier now and could catch Seattle forced to play third-string RB DeeJay Dallas if Chris Carson and Carlos Hyde have to miss a second straight week because of injuries.