I'll take nearly 3 TD's against a Louisville team that is 2-6 and has lost six of its last seven games. The Cardinals are without their star running back Javian Hawkins, who opted out of the season, and could be minus their star wide receiver, Tutu Atwell, too. He's questionable due to injury. 
Syracuse isn't good either. But the Orange will be at full strength for the first time in a month. That will aid their rotation depth. They also are off a bye, which will help freshman QB JaCobian Morgan. Syracuse hung in against Boston College in its last game, losing 16-13 as 14 1/2-point 'dogs. Morgan was 19-of-30 for 188 yards and a TD in that game. 
If there's one thing Syracuse does well it is come up with takeaways forcing 17. That ranks second nationally. Louisville, by contrast, has committed 18 turnovers. Only three teams have lost the ball more.