The Cardinals are an improving team that is struggling right now held in check the past two weeks by the Seahawks and Patriots, neither of whom's defense can compare to the Rams. Kyler Murray may not be 100 percent. 
The Rams are the best team in football if you go by yardage, having the largest differential in the league. LA ranks in the top-five in all of the major defensive categories. Aaron Donald is the most disruptive lineman in the NFL and Jalen Ramsey is that rare cornerback who can handle DeAndre Hopkins. 
LA's balanced offense can control clock and take advantage of a mediocre Arizona defense that has multiple defensive line injuries and is minus its star pass rusher, Chandler Jones. 
The Rams have owned the Cardinals beating them the past six times going 5-0-1 ATS. Arizona would be 0-4 in its last four home contests if not for a successful Hail Mary against the Bills and an overtime victory against Seattle. 
Under Sean McVay, the Rams have won 21 of 31 road games going 19-12 (61 percent) ATS.