The Texans' season was really done when Bill O'Brien foolishly gave away DeAndre Hopkins. Deshaun Watson is doing the best he can but he has no ingredients. The Texans are one of the five-worst teams in the NFL. They rank last in rushing and second to last in stopping the run. They also give up the second-most yards. 
The Colts dominate the trenches in this matchup. Jonathan Taylor and Philip Rivers are in line for huge games. The Texans lost their nose tackle, Brandon Dunn, and are minus their top cornerback, Bradley Roby to suspension. The Texans have allowed 25 TD passes with just three interceptions while surrendering the highest passer rating in the league.
The teams met just two weeks ago and the Texans managed to hang in losing, 26-20. Since then the Texans have lost Will Fuller and Roby. Now this game has become far more of a mismatch than this spread shows. I expect Indy to win by double-digits.