Quarterbacks usually get the most attention. But this matchup features the two best all-purpose running backs in the NFL, Dalvin Cook and Alvin Kamara. 
The Vikings have racked up at least 27 points in six of their last eight games. Only four teams have produced more yards than Minnesota. New Orleans' defense has seen some slippage during the last two weeks. 
The Saints' defense also carries a heavy fatigue rating. They were on the field for a staggering 98 snaps against the Chiefs last Sunday. They catch a bad break that this game is on Friday afternoon giving them much less rest time. 
The Saints are going to get their points against a ravaged Vikings defense that showed nine players on the injury report. Minnesota's best defensive player, linebacker Eric Kendricks, is expected to miss his third straight game because of a lingering calf injury. 
A decimated defensive line, linebacker injuries and inexperienced cornerbacks have caused a steep decline in the Vikings' defense this season. Minnesota just surrendered 33 points to a Mitch Trubisky-led Bears offense last week. 
The Vikings dealt the Saints brutal playoff losses in two of the last three seasons. So Sean Payton won't be adverse to running up a score if the Saints should break way ahead. Drew Brees should also be far more effective having gotten the rust off last week. 
Playing on carpet inside a dome is another plus for the Over.