Death, taxes and Louisville defeating Virginia Tech. The Cardinals have beaten Virginia Tech 16 straight times.
Look for that streak to continue. 
Louisville is 5-0 at home. The Cardinals are playing well and have the shooters to take advantage of the Hokies' below-average 3-point defense. 
Virginia Tech hasn't played in more than a week because it's scheduled game against Virginia for this past Saturday was postponed because of COVID-19 issues on the Cavaliers' side. Not only will the Hokies be rusty, but this is their first game away from Blacksburg since Nov. 29 and first true road game. They've played seven of their nine games at home with the other two being at neutral sites. 
Virginia Tech has failed to cover in six of its past seven away matchups.