It's not so much who you play, but when you play them. That's a major handicap when dealing with the NBA regular season. It's a reason why I'm backing the underdog Cavaliers, who are 1-5 in their last six games and coming off three blowout home losses while the Suns are 5-1 in their last six games. 
Phoenix has opened its current seven-game homestand with victories against the Pistons and Celtics on Sunday. Following this game, the Suns host the Bucks on Wednesday and then 76ers on Saturday. The Suns are fat and happy right now with a pair of far more challenging and marquee matchups on deck. 
Cleveland, though, is improved. The Cavaliers have talent with Andre Drummond and an underrated backcourt of Collin Sexton and Darius Garland. Yes, the Cavs were blown out at home in their last three games. Two of those losses came to the Bucks and the other came against the Clippers, who had both Kawhi Leonard and Paul George in their lineup. Those are "A" level opponents. Phoenix isn't in that class. 
The Cavaliers want to begin again and this is their chance, the start of a five-game West Coast trip. Cleveland ranks ninth defensively, but 29th in scoring averaging 103.6.
The Suns, however, are averaging only 105.5 points in regulation during their past seven games. That's fewer than two points more per game than Cleveland. Phoenix also carries a fatigue rating. This is the Suns' fourth game in six days and second in two days.