I'm not going to land on the Timberwolves too much, but this is one of those rare spots. 
Chicago is fat and happy riding a two-game win streak and seeing Zach LaVine being named the first Bulls player to make the All-Star team since 2017. Chicago's victories, however, have come against the Kings, losers of eight in a row, and the Rockets, who also have dropped eight consecutive games. LaVine is the NBA's seventh-leading scorer, but maybe the worst defender in the league. 
The Timberwolves played their first game under new coach Chris Finch last night. Unfortunately for Finch it came against the Bucks - and the Timberwolves were predictably blown out. This matchup, though, should prove far more even. The Timberwolves have the best big man on the court by far in Karl Anthony-Towns and should play hard for their new coach in what shapes up as a competitive spot. 
Minnesota actually has been very good in this role - 8-2-1 ATS the past 11 times versus sub .500 opponents. The Timberwolves also have covered eight of their last 10 meetings versus Chicago, who has a losing spread mark this season when favored.