One of these teams is being disrespected with this betting line - and it's not Creighton. 
I understand Ohio University isn't held in high regard being from the Mid-American Conference. But all the Bobcats do is cover spreads. They have covered 76 percent of their past 29 games, including going 5-0 ATS the past five times as an underdog. Ohio deserves respect for not only beating Toledo and Buffalo in the MAC Tournament, but taking out Virginia, 62-58, in the first round of the NCAA Tournament. 
According to the Kenpom adjusted offensive efficiency ratings, the Bobcats rank 30th. They have a balanced scoring attack and showed their defensive abilities holding high-scoring Buffalo 13 points below its season average. Jacob Preston gives Ohio one of the best all-around players in the country. 
Creighton has endured a difficult season. The Bluejays shouldn't be trusted in this point spread range. They were extremely fortunate to get past lightly regarded Santa Barbara, 63-62, in the first round. I also don't trust Creighton's current form. The Bluejays are averaging a puny 56.6 points per game during their last three games.