I'm going to side with veteran Kyle Hendricks at a plus price pitching at home against rookie Joe Ryan. 

Hendricks is having a disappointing season, but he's a proven commodity and he knows how to navigate tricky winds at Wrigley Field. Those are the weather conditions in today's games with winds at 23 mph blowing in. Hendricks won't lack motivation as this likely will be his final home start. 

Ryan has looked good for Minnesota - but the sample is short. This is his fourth big league start. Two of them came against the weak-hitting Indians. The other was against these same Cubs, who got to him for three runs in five innings on Sept. 1. So the Cubs are familiar with Ryan.

Note the Twins are 0-5 the past five times they've been interleague favorites.