Seattle swept San Francisco last season and the Seahawks should win this game because of Russell Wilson. He has the arms, legs and intelligence to take advantage of the 49ers' cluster injury situation in their secondary.

Wilson is on pace for career highs in many of the major categories. The 49ers have trouble with mobile QB's. Wilson gives the Seahawks a monster QB edge. The 49ers are a running team lacking a lead runner due to injuries.

Seattle has dominated this series from a point spread perspective going 13-5-1 ATS during the last 19 meetings.

The 49ers also have dropped their last five games at Levi's Stadium.