The Colts have failed to cover in their last seven season-openers. Expect that streak to continue. Division underdogs in Week 1 traditionally fare well. That should be the case here especially given Indy's history. Going back to 2014, the Colts are 0-8 SU, 1-7 ATS opening week. This includes an 0-4 SU and ATS mark under Frank Reich.

Indy didn't look good during preseason. The Colts are making the transition to a new QB - Matt Ryan. And his best days are behind him. Ryan also has a below average wide receiving corps with Michael Pittman the only reliable wideout. The Colts also are minus a couple of key defensive pieces. Star linebacker Darius Leonard is hurt and Matt Eberflus, their ace defensive coordinator, is gone, taking over as the Bears' head coach.

The Texans aren't the worst team in the NFL. They actually are better than perceived on the offensive line, quarterback where Davis Mills flashed last season and at running back where promising Dameon Pierce has taken the No. 1 role. Pep Hamilton is one of the more underrated offensive coordinators. The Texans held their last four opponents to an average of 24 points, a below average figure but not disastrous. Houston went 3-0 in preseason while holding their opponents to an average of 11 points a game.

The Texans won't lack motivation in Love Smith's debut as their head coach. The Colts swept the Texans last season by a combined score of 62-3. Indy hadn't defeated the Texans by more than a touchdown during the previous six meetings before last year.