Colin Kaepernick is at his best when his ground game is going smoothly. That will be the case in this matchup. The 49ers rank No. 3 in rushing thanks to a hot Frank Gore, who has rushed for 299 yards while averaging 4.9 yards per carry during his last four games. Gore has had some of his best performances against the Rams, having scored 14 touchdowns against them while running for more than 1,100 yards.

St. Louis permits nearly 30 points a game and is second-to-last in stopping the run. The Rams have allowed 100-yard rushers in three of their last four games.

Don't be fooled by the Rams ranking No. 1 in pass defense. Their secondary actually isn't very good at all. They've faced the fewest pass attempts per game. Opposing quarterbacks have completed close to 71 percent of their throws against the Rams. The Rams are last in the league in sacks, too, with just one.

San Francisco owns the superior offense and defense. The 49ers are 8-1-1 ATS in their last 10 road and neutral site games, not including playing in Seattle.