Taking SAN FRANCISCO here. Will back the Niners as small home faves. First, we got the revenge angle here. They were totally embarrassed 29-3 to start the year. SF had 5 turnovers and took a safety. We also have Seattle off a MNF beat-down of another NFC front-runner, the Saints. I know it won't be hard to 'get up' for this game on a short week. But they were pretty physical Monday, and SF knows this team a little better than NO. We can't overlook the fact that the Seattle defense is down a couple starters. Seattle is a different beast on the road. They have lost 5 straight here in SF. But just looking at this year. They played a 12-7 game vs Carolina. 23-20 at Houston. A loss at Indy 34-28. 14-9 win at St Louis. Their 2 big road wins, 34-22 at ARZ and 33-10 at Atlanta. SF is neither of those teams. SF is in a desperate state. They need to win to keep pace with Carolina and the Saints. 5* Best Bet SAN FRANCISCO 49ers