The NFL dog with bite is on the SF 49ers.Game 464 at 4:25 eastern. The Saints are off an upset home dog win over Seattle and fall into a play against system that pertains to road favorites. The Saints are 2-10 ats vs .400 or less teams and 1-6 ats as non division favorites of 3 or more. They have failed to cover the last 5 in this series. The Niners are off 6 losses and and fall into a play on system vs a team off a dog win. They have the benefit of a bye week which tends to rejuvenate inept teams. Coach Payton is 1-13 to the spread off a spread win of 6 or more vs a team off 2+ losses. The Saints are 0-9 ats as a -3.5 or more favorite after Breese threw for 250+ pass yards. Play on San Francisco