The San Francisco 49ers are still in search for their first win of the season, but I like their chances here when they visit the Indianapolis Colts in Week 5.

The Niners fought hard in last week's 18-15 OT loss at Arizona, and they did a great job defensively holding the Cardinals to just 51 yards on the ground. Note that San Francisco has covered the spread in three straight games since taking a 23-3 beating by Carolina in Week 1.

The Colts meanwhile are coming off a 46-18 loss as a 12.5-point dog at Seattle. Indianapolis' defense ranks dead last for points allowed per game (34.0) and 2nd last in total defense giving up 396.3 yards per game. The Colts' lone win on the season was a 31-28 victory against Cleveland in Week 3, so nothing to brag about.

San Francisco has looked pretty good on the defensive side of the ball this season, and Carlos Hyde can do a lot of damage carrying the ball.

My selection is an 8* play on San Francisco 49ers.