The Arizona Diamondbacks are 6-1 on the season and defeated the Cards 3-1 in the opener of this three-game series on Thursday.

Here they'll hand the ball to Zack Greinke who held Colorado to one run on five hits with nine strikeouts and no walks over 5 2/3 innings in his season debut. Greinke has traditionally has been tough on St. Louis, going 12-4 with a 3.17 ERA in 18 career starts.

The Cardinals turn to Michael Wacha (0-1, 7.71 ERA) who gave up four runs on five hits (two homers) through 4 2/3 frames against the Mets in his first start of the season. Wacha tossed six scoreless innings against the D'Backs last season but I don't think he'll get enough run support in this contest.

8* play on Arizona Diamondbacks.