The Arizona Cardinals are coming off three consecutive straight up losses, but they're 5-1 ATS over their last six games. That stretch includes a tight 28-25 home loss to the 49ers, and I like them to keep it close at San Francisco this week.

The Niners fell in OT against Seattle last week, their first defeat of the season. I would not be surprised to see them come out flat here with no undefeated record to defend, and several of quarterback Jimmy Garoppolo's weapons are hurting.

Will San Francisco bounce back with a win? Almost certainly, but I think the Niners will find themselves in a much closer game than they might expect.

Cardinals are 5-2 ATS in their last 7 vs. NFC West. 49ers are 2-7 ATS in their last 9 vs. NFC West. Underdog is 5-1 ATS in their last 6 meetings.

10* play on Arizona Cardinals.