The Colts are going on the road in search of their first win of the season following home losses to Seattle and LA Rams. QB Carson Wentz (ankle sprain) might miss the game, but I expect to see a reaction and plenty of desperation to avoid starting the season with three straight losses.

As for the home team, the Titans are coming off a dramatic 33-30 overtime victory last week at Seattle. While they have a win to their name, their defense has been an issue with 400+ yards of total offense allowed per game and they have injury concerns in their secondary.

Colts are 5-1 ATS in their last 6 road games. Colts are 14-5 ATS in their last 19 meetings. Road team is 5-0 ATS in their last 5 meetings.

8* play on Indianapolis Colts.