Both teams have already qualified for postseason football, and they've both announced that they'll rest starters. This will add more variance, making the underdog even more attractive from a betting perspective and the Rams typically match up very well against the Niners.

Additionally, while the Niners are coming off a 27-10 rout of Washington, note that the 49ers are 1-4 ATS in their last 5 games following a straight up win of more than 14 points.

4* PLAY ON THE RAMS.