The set-up: I like the Lions to bounce back on the road here after a tough setback in Week 1. The 49ers also lost in Week 1 and I think they're ripe for the picking.

The teams: Detroit was humbled 48-17 last week and new head coach Pat Patricia is already on the hot seat. The Lions would give up 31 third-quarter points: "It came to a point there in the third quarter where we just didn't have control anymore in all three phases," Patricia assessed. "We just have to do a better job. Obviously, we have to coach this a lot better than what we did tonight and we have to go out and execute a lot better on the field. We have to do a better job altogether. It starts with me." QB Matt Stafford had 286 yards, while the defense allowed 169 rushing yards.

San Francisco didn't look too much better in its 24-16 loss at Minnesota. QB Jimmy Garoppolo looked poor, going 15 of 33 for 261 yards, one TD and three INT's. Is there any QB more over-rated than this guy? The 49ers finished with just 13 points on four trips inside the Red Zone. The team lost the services of WR Marquise Goodwin to injury also.

The pick: Take it for what you will as well, but San Francisco is just 5-11 ATS in its last 16 at home and only 1-4 ATS in its last five as a favorite. I expect a hard-fought battle, one which will likely be decided by whichever of these hungry sides has its hands on the ball last. Grab the points.