The set-up: The 49ers have ben ravaged by injury early. Jimmy Garopolo only played a half in last week's 43-17 loss to the Dolphins, but he's expected to start this week. San Francisco though still has many holes on both sides of the ball. The Rams are 4-1 and they're playing exceptional defense right now, allowing only 18 points and 330 yards of total offense per game. If San Francisco has troubles moving the ball on the Fish, I can't see it having much luck in this divisional contest vs. this elite defense. The Rams have also gotten great play from Jared Goff, who has limited the turnovers in the early going.

The pick: San Francisco is just 1-6 ATS in its last seven after allowing more than 250 passing yards in its previous game as well, while the Rams are 4-0 ATS in their last four road games vs. a team with a losing record. This one has lop-sided "blowout" written all over it. Lay the points.

This is a 10* GAME OF THE WEEK on the LA Rams.