The Denver Broncos will host the San Francisco 49ers in a Week 3 pre-season meeting this Saturday. The Broncos are 2-0 so far, and I think they'll stay undefeated as the 49ers don't have enough weapons to keep up offensively.

Here are my keys to the game:

1. Peyton Manning - The Broncos quarterback has yet to get going, but he should see plenty of time here in this game. The Broncos beat San Francisco 34-0 in a pre-season game last August, and Manning threw for 102 yards and a TD on 10-of-12 passing.

2. Denver Defense - The Broncos have one of the fiercest pass rushes in the NFL, and that was on full display as they sacked Houston's quarterbacks five times for a loss of 32 yards last week. San Francisco's quarterback Collin Kaepernick was sacked for a 14 yard loss last week, and he's been known to hang on to the ball longer than he should.

3. X-Factor - Manning threw for 318 yards and four TDs in a 42-17 home win versus San Francisco last October. Kaepernick was picked off once, and sacked six times in that game.

Selection: This is a play on the Denver Broncos (10*)