Florida State: The Seminoles are ranked No.2 and like the nation's No. 1 team (Alabama) and its No. 3 team (Ohio State), FSU is playing a ranked team on the road this Saturday. FSU knows all about Ole Miss, beating the Rebels 45-34 in Orlando on Labor Day evening, then followed with a 52-8 rout of Charleston Southern which, coupled with then-No. 2 Clemson's narrow 30-24 escape against Troy, allowed the Seminoles to leapfrog their ACC rivals from No. 3 to No. 2 in the latest AP rankings. However, preseason All-American defensive back Derwin James suffered a cartilage tear in his left knee during the Charleston Southern game and could be out as long as 10 weeks, or as little as two, Seminoles coach Jimbo Fisher said. RB Dalvin Cook was among the preseason Heisman favorites but he's counted for a modest 284 total yards and two TDs in limited action. Redshirt freshman QB Deondre Francois has been the offensive star so far for FSU, completing 69.0 percent for 681 yards with five TDs and just one INT.

Louisville: FSU's Francois has been terrific but no QB in the nation is off to a better start than Louisville's Lamar Jackson. Jackson threw for six TDs and 286 yards and added 119 rushing with two more TDs in a 70-14 opening season win over Charlotte. He then set an ACC record with 610 total yards of offense last week versus the Orange (a 62-8 Louisville win) and became the first player in FBS history to record over 400 yards passing (411) and 175 yards rushing (199) in the same game, helping the Cardinals set another school record with 845 total yards. Jackson and RB Brandon Radcliff (156) each topped 100 yards rushing, while receivers Jamari Staples (136) and James Quick (108) each went over 100 yards receiving, giving Louisville its first-ever pair of 100-yard rushers and 100-yard receivers in the same game. The Cardinals are averaging a FBS-best 754 yards of total offense, which is 138 more than Baylor's top-ranked offense from a season ago and 338 more than Louisville averaged in 2015.

The pick: The marks the 17th meeting between the two teams but just the third as conference opponents. However, the Cardinals have won only two of the previous 16 meetings, going a modest are 1-5 at home against the Seminoles. Florida State has won the previous two meetings when playing as ACC foes but trailed in both games. The Cardinals jumped out to a 21-0 lead in the second quarter in 2014, before Heisman winner Jameis Winston rallied the Seminoles to a 42-31. The Cardinals led 7-6 at the half last year but the 'Noles turned the game into a 41-21 romp.

What will be different this year? Yes, Lamar Jackson has compiled 1,015 yards of total offense and accounted for 13 TDs in less than two full games for Louisville, but these have regularly been the type of games FSU wins and Louisville loses. Bobby Petrino will have to wait for another situation for the biggest win of his second go-round at Louisville. FSU is a 10* play.