Iowa State is 13-3 ATS as a home favorite this season. The Cyclones are also rated third overall at home (behind Houston and Purdue) and second in adjusted defensive efficiency on their floor.
BYU is just 1-4 ATS as a road underdog, but they did beat Kansas 76-68 on February 27. Expect a letdown here. The last seven games that BYU has lost outright have been at least seven points or more.
Give me Iowa State here.