The Chargers are 4-3 on the road this season, but only one of those wins came by more than three points, and it was against the Texans on Week 4.
The Colts have either led or been within two points in each of their last five games through three quarters. I see Nick Foles giving the Colts a spark at home after the back-to-back fourth-quarter collapses. This feels like a game Indianapolis keeps within three.

Chargers are 1-3-1 in last five as a favorite.
Colts are 3-1 ATS in last four as an underdog.